ARA-290 (Cibinetide): A Research Overview of the Cytoprotective Peptide

What Is ARA-290? ARA-290, also known by its International Nonproprietary Name cibinetide, is an 11-amino-acid linear synthetic peptide derived from the three-dimensional structure of erythropoietin (EPO). Specifically, it is modelled from the helix-B surface region of the EPO molecule — the domain responsible for tissue-protective signalling. Unlike recombinant EPO, ARA-290 does not stimulate erythropoiesis (red blood cell production). Instead, it selectively activates the innate repair receptor

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