The Biochemistry of MOTS-c: A Structural Analysis of Mitochondrial-Derived Peptides
Introduction: Defining MOTS-c as a Mitochondrial-Derived Peptide MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-c) is a 16-amino-acid peptide encoded by the mitochondrial 12S rRNA gene (MT-RNR1). First characterised in 2015 by Lee et al. at the University of Southern California, MOTS-c represents a distinct class of bioactive molecules known as mitochondrial-derived peptides (MDPs) — short open reading frames hidden within the mitochondrial genome that produce functional sign
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