MOTS-c: The Mitochondrial-Derived Compound Reshaping Metabolic Research

What is MOTS-c? MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a small bioactive compound encoded within the mitochondrial genome — specifically within the 12S ribosomal RNA gene. It consists of 16 amino acids with the sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg and has a molecular weight of approximately 2,174 Da. First identified and characterised by researchers at the University of Southern California in 2015, MOTS-c was a landmark discovery in the

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